METABOLISM OF KETONE BODIES
Three related compounds, namely acetoacetate. B hydroxybutyrate and acetone are collectively known As ketone bodies. An organ involved in biosynthesis – liver
Organelle involved - mitochondria (matrix)
Substrate for biosynthesis - acetyl CoA
Acetoacetate and acetone are true ketones, but B-hydroxybutyrate does not contain a keto group.
• These are water-soluble energy-yielding substance.
Acetoacetate and B- hydroxybutyrate is carried to the extra-hepatic tissue where they are metabolized and gives energy.
On the other hand, acetone is not metabolized and readily exhaled through the lungs.
• Plasma concentration is around 1mg/dl.
• Normal excretion of ketone bodies through urine is less than 1mg/day.
No comments:
Post a Comment