EXCESS PRODUCTION OF KETONE BODIES

EXCESS PRODUCTION OF KETONE BODIES

• Normally, ketone body synthesis, and oxidation are balanced so that their serum concentration is maintained around Img/dl, and urinary excretion is negligible (Img/day). Rothera's test can not detect such a low concentration of ketone bodies in urine. 

• However, if the rate of production exceeds the rate of oxidation, ketone bodies accumulate in the blood.

• Ketonemia:

 When the concentration of ketone bodies in the blood rises above normal, the condition is known as ketonemia.

• Ketonuria:

 When excess ketone bodies are detected in urine, the condition is known as ketonuria.

• Ketosis: 

The overall picture of ketonemia and ketonuria is known as ketosis.

• Ketoacidosis: 

It is a state in which acidosis develops due to excess accumulation of acetoacetate and B-hydroxybutyrate in the blood and also appears in the urine.